We have a second publication out this year. This work is a major collaboration between chemists and biologists to find new chemical inhibitors of the enzyme Chk1. The chemistry was led by Dr Françoise Perron-Sierra and Dr Patrick Casara; they developed a new method to modify an amazing class of compounds known as "indolocarbazoles". By testing these new molecules we found several potent inhibitors of Chk1. These compounds add to our arsenal of tools to study how cancer cells enter mitosis with damaged DNA. The compounds also have potential as anti-cancer agents in solid tumours and leukaemias.
If you have questions or would like to know more, feel free to contact either myself (roy.golsteyn@uleth.ca) or Françoise (francoise.perron-sierra@fr.netgrs.com).
