Our manuscript is accepted in the Biochemical Journal. It is a too brief moment of satisfaction of completing a project. A special thanks to the experimentalists who succeeded in converting the complex problem of cell division with damaged DNA into a powerful experimental model. Of the cell lines we tested, HT-29 cells have features that provide a window of the key transition point of entry into mitosis after a checkpoint.
What's next - we have developed a non-radioisotope assay to measure enzyme activity in mitotic cells; we are testing how to block checkpoint adaptation, and we are looking very closely at the DNA in cancer cells that survive checkpoint adaptation.
If interested, please feel free to contact us for questions, reagents or a copy of the paper.
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