We have submitted a manuscript on our principle project. This is the period of calm that lays between the rush to submit and the time before one receives comments from the reviewers. The manuscript describes how human cancer cells undergo checkpoint adaptation: a sort of "double or nothing" cellular game in which cells will divide even though they have damaged DNA. The manuscript connects the dots of hundreds of observations described in the literature where mitosis has been observed in cells treated with DNA damaging agents. We have mapped this terrain in a systematic fashion. We then go beyond mapping by proposing a mechanism to explain the steps to enter mitosis under these conditions. The important bit is that once you have a good map you can plan where you should go next.
Please feel free to contact me for more information or for a preprint, while the calm lasts.
